Principal Scientist, Toxicology (m/f)

  • Function as project toxicologist to develop and design nonclinical toxicology program and strategies to advance early oncology targets into candidate selection and early clinical trials
  • Design, direct, and monitor exploratory and GLP toxicity studies to support IND submission and/or advanced development stages
  • Develop early nonclinical in vitro and in vivo safety screening assays and studies for de-risking strategies to help Discovery teams to progress early oncology targets into candidate selection stage
  • Design and conduct hypothesis-driven investigative studies, or establish appropriate preclinical models, as needed, to better characterize the toxicity profile of the target and/or platform, and preclinical to clinical translational
  • Design and conduct mechanistic studies to mitigate key toxicities associated with target and / or platform
  • Work with toxicology study teams (internally or contract laboratory) on design, protocol development, and recommendation for appropriate end-points and study-related challenges
  • Ensures timely and accurate communication of study results and interpretation to project teams
  • PhD in Toxicology or other relevant field (such as DVM) with at least 8+ years of industry experience (or Bachelors / Masters with equivalent experience with 12 plus years of industry experience) as a study director / monitor in toxicology
  • Experience specifically supporting drug discovery research and development from a toxicology standpoint
  • Experience in designing, conducting, monitoring and interpreting nonclinical toxicology / research studies
  • Certification by the American Board of Toxicology (DABT) highly desired. Experience in oncology highly desired

» Job description

AbbVie Inc.
San Francisco [USA]

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